The Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts
Skin is the largest organ in the body comprised of three different layers including the epidermis, dermis, and hypodermis.The dermis is mainly composed of dermal fibroblasts and extracellular matrix (ECM), such as collagen and elastin, which are strongly related to skin elasticity and firmness.Skin is continuously exposed to different kinds of envi